|
KMID : 0351619770180010117
|
|
Kyungpook Medical Journal
1977 Volume.18 No. 1 p.117 ~ p.125
|
|
|
Amylase-Creatinine Clearance Ratio in Acute Pamereatitis and Non-Pancreatic Conditions with Acute Abdominal Pain
|
|
金秉九/Kim, Byung Gu
張性國/郭圭植/鄭俊謨/鄭克守/Chang, Sung Gug/Kwak, Kyu Sik/Chung, Joon Mo/Chung, Keuk Soo
|
|
|
Abstract
|
|
|
The serum amylase test is routinly used as a diagnostic method of acute pancreatitis. However in many non-pancreatic conditions such as acute cholecysititis, ileus, mumps, intestinal perforation and kidney trouble, we can observe hyperamylasemia. Therefore, hyperamylasemia only have not specific diagnostic meaning for acute pancreatitis. Also urine amylase test is available but its data is conflicting and in consequence urine amylase test is ~:nfrequently used in practice.
Recently in 1969, Levitt et al introduced amylase-creatinine cle~irance ratio which would enhance the diagnostic value of amylase determination in acute pancreatitis. Thereafter many interesting data were reported for supporting Levitt´s results.
The author examined on amylase-creatinine clearance ratio in total 89 cases of various diseases with acute abdominal pain including 23 cases of acute pancreatitis, 9 cases of biliary tract diseases accompanying acute pancreatitis, 2 -cases of relapsing pancreatitis, 9 cases of biliary tract diseases without pancreatitis, 14 cases of liver diseases and 16 cases of various gastric diseases and results obtained were as follows.
Amylase-creatinine clearance ratio(Cam/Ccr) of the liver, biliary tract and stomach diseases were 1.92 .1.63%, 1.890.41% and 1.760.52% respectively (Cam/Ccr in healthy Korean adult as a control was 1.86=0.3jo).
Cam/Ccr in acute pancreatitis, acute pancreatitis accompanied by biliary tract diseases and relapsing pancreatitis wire 4.751.38%, 4.361.31% and 4.23-1.87% respectively and they were significantly higher than healthy control (*P<0.05).
Serum amylase in acute pancreatitis was seen to be elevated on 14 days of illness while urine amylase remained more or less higher level than the healthy control up to 1015days. Cam,-"Ccr of acute pancreatitis showed significantly high level from the first day of i:iiness, recording peak level on 5--10 illness days. rind then it gradually came down _but still showed higher level than the control even on 1C15 illness days when the serum amylase level had become within no. mal range.
Cam/Ccr in those with acute pancreatitis, acute pancreatitis, ace 7p7iaizU lay bil_ai ~; ~: aet diseases and in those with biliary tract ..diseases without pancreatitis, who showed Mail serum amylase level of over 300 Somogyi units and differential diagnosis by physical examination or usual laboratory findings was difficult, were 5.1,30.8%, 4.931.20% and 1.92+0.51% res pectively and the former two (cases with acute pan~creatitis, primary or secondary) were significantly higher than the last (cases without pancreatitis) (p <0.05).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|